Who revealed biochemical nature of the transforming principle ? How was it done ?
Who revealed biochemical nature of the transforming principle ? How was it done ?
Oswald Avery, Colin MacLeod and Maclyn McCarty ($1933$-$44$), worked to determine the biochemical nature of 'transforming principle' in Griffith's experiment. They purified biochemicals (proteins, $DNA$, $RNA$, etc.) from the heat-killed S cells to see which ones could transform live $R$ cells into $\mathrm{S}$ cells. They discovered that $DNA$ alone from $S$ bacteria caused $R$ bacteria to become transformed.
They also discovered that protein-digesting enzymes (proteases) and $RNA$-digesting enzymes ($RNases$) did not affect transformation, so the transforming substance was not a protein or $RNA$. Digestion with $DNase$ did inhibit transformation, suggesting that the $DNA$ caused the transformation. They concluded that $DNA$ is the hereditary material, but not all biologists were convinced.
Similar Questions
$DNA$ is the genetic material because
$DNA$ is the genetic material because
Given below are two statements:
Statement $I:$ $RNA$ mutates at a faster rate.
Statement $II$: Viruses having RNA genome and shorter life span mutate and evolve faster.
In the light of the above statements, choose the correct answer from the options given below:
Given below are two statements:
Statement $I:$ $RNA$ mutates at a faster rate.
Statement $II$: Viruses having RNA genome and shorter life span mutate and evolve faster.
In the light of the above statements, choose the correct answer from the options given below:
- [NEET 2023]
In some viruses, $RNA$ is present instead of $DNA$ indicating that
In some viruses, $RNA$ is present instead of $DNA$ indicating that
Which of the following radioactive isotopes were utilised for labelling protein and $DNA$ in transduction experiment respectively?
Which of the following radioactive isotopes were utilised for labelling protein and $DNA$ in transduction experiment respectively?
How it was proved that $DNA$ is the Genetic material ?
How it was proved that $DNA$ is the Genetic material ?