The defect sickle-cell anaemia is caused by the ______ of glutamic acid by valine at the $6^{th}$ position of the ______ globin chain of the haemoglobin molecule.

  • A

    Substitution, $\beta$

  • B

    Deletion, $\alpha$

  • C

     Duplication, $\beta$

  • D

    Translocation, $\alpha$

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