Which of the following is a main challenge fo | vedclass

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(D) In humans,insulin is synthesized as a pro-hormone containing an extra stretch called the $C$-peptide.This $C$-peptide is not present in the mature

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Assembling of insulin into mature insulin

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(D) In humans,insulin is synthesized as a pro-hormone containing an extra stretch called the $C$-peptide.This $C$-peptide is not present in the mature insulin and is removed during maturation.The main challenge for the production of insulin using $r-DNA$ technology was getting insulin assembled into a mature form.Eli Lilly,an American company,prepared two $DNA$ sequences corresponding to $A$ and $B$ chains of human insulin and introduced them in plasmids of $E. coli$ to produce insulin chains.These chains were then extracted and combined by creating disulfide bonds to form mature human insulin.

Which of the following is a main challenge for the production of insulin by the $r-DNA$ techniques?

Similar Questions

What is absent in mature insulin?

Which of the following peptide chain is removed during the maturation of proinsulin into insulin?

Which human medicine was the first to be produced using recombinant $DNA$ technology?

At present,about $X$ recombinant therapeutics have been approved for human use the world over. Out of these,$Y$ are being marketed in India.

Which one of the following is now being commercially produced by biotechnological procedures?

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