Which of the following factors favour the dis | vedclass

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(B) At the tissue level,the partial pressure of oxygen $(PO_2)$ is low,and the partial pressure of carbon dioxide $(PCO_2)$ is high due to metabolic a

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$PO_2 \downarrow, PCO_2 \uparrow, [H^+] \uparrow, 	ext{Temperature} \uparrow$

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(B) At the tissue level,the partial pressure of oxygen $(PO_2)$ is low,and the partial pressure of carbon dioxide $(PCO_2)$ is high due to metabolic activity.Increased metabolic activity also leads to higher concentrations of hydrogen ions ($[H^+] \uparrow$,which means lower $pH$) and increased temperature.These conditions (low $PO_2$,high $PCO_2$,high $[H^+]$,and high temperature) shift the oxygen-hemoglobin dissociation curve to the right,facilitating the dissociation of $HbO_2$ to release oxygen to the tissues.Therefore,the correct factors are $PO_2 \downarrow, PCO_2 \uparrow, [H^+] \uparrow, 	ext{Temperature} \uparrow$.

Which of the following factors favour the dissociation of $HbO_2$ at the tissue level?

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