Sickle-cell anaemia is caused by the followin | vedclass

Name: Exam Paper Generator | JEE NEET Paper Generator | Vedclass
Brand: Vedclass
Rating: 5 (35 reviews)

Question

(A) The correct answer is $GAG-GUG$ (at the mRNA level) or $CTC-CAC$ (at the $DNA$ template strand level).In sickle-cell anaemia,a point mutation occu

Vedclass · Accepted Answer

$CTC$-$CAC$

Vedclass · Answer

(A) The correct answer is $GAG-GUG$ (at the mRNA level) or $CTC-CAC$ (at the $DNA$ template strand level).In sickle-cell anaemia,a point mutation occurs in the $\beta$-globin gene.Specifically,the codon $GAG$ (coding for glutamic acid) is mutated to $GUG$ (coding for valine) at the sixth position of the $\beta$-globin chain.At the $DNA$ level,the template strand codon $CTC$ is mutated to $CAC$,which results in the transcription of $GUG$ instead of $GAG$.This substitution of valine for glutamic acid causes the haemoglobin molecules to polymerize under low oxygen tension,leading to the characteristic sickle shape of the red blood cells.

Sickle-cell anaemia is caused by the following mutant gene mutation ($DNA$ level):

Similar Questions

If a colorblind man marries a woman with normal vision,what is the probability of their son being colorblind?

$A$ colour-blind man marries the daughter of a colour-blind person. Then in their progeny:

$A$ normal woman, whose father was an albino, marries an albino man. What is the expected proportion of normal and albino children in their offspring?

Sickle cell anemia and Huntington's chorea are both ..........

$A$: The heterozygotic female for haemophilia may transmit the disease to sons.
$R$: Such traits show criss-cross inheritance.

Vedclass Test Series

Exam Paper Generator

Online Exam Module