Mention the contribution of microbes in making of antibiotics.

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 Antibiotics produced by microbes are regarded as one of the most significant discoveries of the twentieth century and have greatly contributed towards the welfare of the human society.

- Anti is a Greek word that means 'against' and bio means 'life', together they mean 'against life'. (In the context of disease causing organisms).

Whereas with reference to human beings, they are Pro life and not against.

Antibiotics are chemical substances which are produced by some microbes and can kill or retard the growth of other (disease causing) microbes.

Penicillin was the first antibiotic to be discovered.

When Alexander fleming was working on staphylococci bacteria once observed a mould growing in one of his unwashed culture plates around which staphylococci could not grow. He found out that it was due to a chemical produced by the mould and he named it penicillin after the mould penicillium notatum.

However its full potential as an effective antibiotic was established much later by Ernest Chain and Howard Florey.

$\Rightarrow$ This antibiotic was extensively used to treat American soldiers wounded in world war-$II$.

- Fleming Chain and Florey were awarded the Noble Prize in $1945$ for this discovery.

$=$ After penicillin, other antibiotics were also purified from other microbes.

$\Rightarrow$ Antibiotics have greatly improved our capacity to treat deadly disease such as plague, whooping cough, diptheria and leprosy, which used to kill millions all over the globe.

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$A $ : Statins are product of fermentation activity of yeast.
$R$ : Statins and mevalonate compete for same active site on enzyme involved in cholesterol synthesis.

__$A$__ enzyme is used to remove clots from the blood vessels of patients who have undergone __$B$__ leading to heart attack.

How are microbes useful in industrial production of chemicals, enzymes and other bioactive molecules ?