Mention any two autosomal genetic disorders with their symptoms.

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(N/A) Two autosomal genetic disorders are as follows:
$1$. Sickle cell anaemia: It is an autosomal-linked recessive disorder caused by a point mutation in the beta-globin chain of the haemoglobin molecule. The disease is controlled by $Hb^A$ and $Hb^S$ alleles. Homozygous individuals $(Hb^S Hb^S)$ show symptoms,while heterozygous individuals $(Hb^A Hb^S)$ are carriers.
Symptoms: Rapid heart rate,breathlessness,delayed growth,jaundice,weakness,fever,excessive thirst,chest pain,and decreased fertility.
$2$. Down's syndrome: It is an autosomal disorder caused by the trisomy of chromosome $21$.
Symptoms: Short stature,round head,open mouth,protruding tongue,short neck,slanting eyes,broad short hands,and retarded mental and physical growth.

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