In sickle cell anaemia$-$

  • A
    The mutant haemoglobin molecule undergoes polymerisation under low oxygen tension causing the change in the shape of $\text{RBC}$
  • B
    Substitution of Glutamic acid by valine at the sixth position of the $\alpha-$chain of haemoglobin
  • C
    The mutant haemoglobin undergoes polymerization under high oxygen tension causing the change in shape of $\text{RBC}$
  • D
    $\alpha-$globin chain is modified

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