(A) Thalassaemia is an autosomal recessive blood disorder. Let the normal allele be $T$ and the recessive allele for thalassaemia be $t$. Both parents

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(A) Thalassaemia is an autosomal recessive blood disorder. Let the normal allele be $T$ and the recessive allele for thalassaemia be $t$. Both parents are carriers,meaning their genotype is $Tt$. When crossing $Tt \times Tt$,the possible genotypes of the offspring are $TT$ (normal),$Tt$ (carrier),$Tt$ (carrier),and $tt$ (affected). The probability of an affected child $(tt)$ is $1/4$ or $0.25$.

Class 12 Biology Principles of Inheritance and Variation Pedigree Analysis and Mendelian disorders

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If both parents are carriers for thalassaemia,which is an autosomal recessive disorder,what are the chances of pregnancy resulting in an affected child?

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A
$0.25$
B
$1$
C
No chance
D
$0.5$

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Chapter

Principles of Inheritance and Variation

Subtopic

Pedigree Analysis and Mendelian disorders

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Match Column-$I$ with Column-$II$ and select the correct option.

Column-$I$ Column-$II$

$(P)$ Haemophilia $(i)$ Recessive gene: $X^{h}X^{h}$

$(Q)$ Colour blindness $(ii)$ Recessive gene: $pp$

$(R)$ Phenylketonuria $(iii)$ Recessive gene: $Hb^{s}Hb^{s}$

$(S)$ Sickle-cell anaemia $(iv)$ Recessive gene: $X^{c}X^{c}$

Column-$I$	Column-$II$
$(P)$ Haemophilia	$(i)$ Recessive gene: $X^{h}X^{h}$
$(Q)$ Colour blindness	$(ii)$ Recessive gene: $pp$
$(R)$ Phenylketonuria	$(iii)$ Recessive gene: $Hb^{s}Hb^{s}$
$(S)$ Sickle-cell anaemia	$(iv)$ Recessive gene: $X^{c}X^{c}$