| Glycolysis | Citric acid cycle |
| $(1)$ This process occurs in the cytoplasm of the cell. | $(1)$ This process occurs in the mitochondrial matrix. |
| $(2)$ $O_2$ is not required for this process. | $(2)$ $O_2$ is indirectly required for the regeneration of $NAD^+$ and $FAD$. |
| $(3)$ One molecule of glucose is broken down into two molecules of pyruvic acid. | $(3)$ Acetyl-$CoA$ is completely oxidized to release $CO_2$. |
| $(4)$ It is a linear metabolic pathway. | $(4)$ It is a cyclic metabolic pathway. |
| $(5)$ $CO_2$ is not produced during this process. | $(5)$ Two molecules of $CO_2$ are released per acetyl-$CoA$ molecule. |
| $(6)$ Discovered by Embden,Meyerhof,and Parnas ($EMP$ pathway). | $(6)$ Discovered by Hans Krebs. |
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