Drugs like $LSD$, barbiturates, amphetamines, etc., are used as medicines to help patients with mental illness. However, excessive doses and abusive usage are harmful. Enumerate the major adverse effects of such drugs in humans.

(D) The major adverse effects of the abuse of drugs like $LSD$, barbiturates, and amphetamines include:
$1$. $Central \ Nervous \ System \ (CNS)$ impairment: These drugs directly affect the brain, leading to altered perception, hallucinations, and impaired judgment.
$2$. $Psychological \ dependence$: Users often develop a strong psychological craving for the drug, leading to addiction.
$3$. $Physical \ health \ deterioration$: Chronic abuse can lead to cardiovascular issues, respiratory depression, liver damage, and neurological disorders.
$4$. $Behavioral \ changes$: Abuse often results in mood swings, aggression, social withdrawal, and a decline in cognitive performance.
$5$. $Withdrawal \ symptoms$: Abrupt cessation of these drugs can cause severe anxiety, tremors, seizures, and in extreme cases, death.