Describe Mendelian Disorder
Describe Mendelian Disorder
Mendelian disorders are mainly determined by alteration or mutation in the single gene. These disorders are transmitted to the offspring on the same lines as we have studied in the principle of inheritance.
The pattern of inheritance of such Mendelian disorders can be traced in a family by the pedigree analysis.
Most common and prevalent Mendelian disorders are Haemophilia, Cystic fibrosis, Sickle-cell anaemia, Colour blindness, Phenylketonuria, Thalesemia, etc. It is important to mention here that such Mendelian disorders may be dominant or recessive.
By pedigree analysis one can easily understand whether the trait in question is dominant or recessive. Similarly, the trait may also be linked to the sex chromosome as in case of haemophilia.
It is evident that this $X-$linked recessive trait shows transmission from carrier female to male progeny. A representative pedigree is shown in Figure for dominant and recessive traits,
Similar Questions
$A$ : The posssibility of a female becoming a haemophilic is extremely rare.
$R$ : Mother of such a female has to be carrier and father should be haemophilic
$A$ : The posssibility of a female becoming a haemophilic is extremely rare.
$R$ : Mother of such a female has to be carrier and father should be haemophilic
Among symbol $A, B$ and $C, C$ indicates
Among symbol $A, B$ and $C, C$ indicates
A husband and wife have normal vision but fathers of both of them were colour blind. Probability of their first daughter to be colour blind is
A husband and wife have normal vision but fathers of both of them were colour blind. Probability of their first daughter to be colour blind is
- [AIPMT 1990]
Select the correct sentence for colour blindness ?
Select the correct sentence for colour blindness ?
If a haemophilic man marries a woman carrier (heterozygous) for haemophilia, what would be the possibility that their daughter would be haemophilic
If a haemophilic man marries a woman carrier (heterozygous) for haemophilia, what would be the possibility that their daughter would be haemophilic