Assertion : Acylation of amines gives a monos | vedclass

Name: Exam Paper Generator | JEE NEET Paper Generator | Vedclass
Brand: Vedclass
Rating: 5 (35 reviews)

Question

(C) The assertion is correct: Acylation of amines (using acid chlorides or anhydrides) results in a monosubstituted product because the electron-withd

Vedclass · Accepted Answer

If the Assertion is correct but Reason is incorrect.

Vedclass · Answer

(C) The assertion is correct: Acylation of amines (using acid chlorides or anhydrides) results in a monosubstituted product because the electron-withdrawing nature of the acyl group reduces the nucleophilicity of the nitrogen atom,preventing further acylation. In contrast,alkylation of amines (using alkyl halides) leads to a mixture of primary,secondary,tertiary amines,and quaternary ammonium salts because the alkyl group is electron-donating,which increases the nucleophilicity of the nitrogen atom,making it more reactive toward further alkylation. The reason is incorrect: The limitation of acylation is due to the electronic effect (electron-withdrawing nature of the acyl group) rather than steric hindrance. Therefore,the assertion is correct,but the reason is incorrect.

Assertion : Acylation of amines gives a monosubstituted product whereas alkylation of amines gives polysubstituted product.
Reason : Acyl group sterically hinders the approach of further acyl groups.

Similar Questions

For the diazonium ions,the order of reactivity towards the diazo-coupling with phenol in the presence of dilute $NaOH$ is:
$(I)$ $Me_2N-C_6H_4-N_2^+$
$(II)$ $O_2N-C_6H_4-N_2^+$
$(III)$ $CH_3O-C_6H_4-N_2^+$
$(IV)$ $CH_3-C_6H_4-N_2^+$

Reaction of nitrous acid with aliphatic primary amine in the cold gives

The decreasing order of basicity is:
$(1) \ CH_3CONH_2$
$(2) \ CH_3CH_2NH_2$
$(3) \ PhCH_2CONH_2$

Identify $Z$ in the following sequence of reactions.

The order of basic strength of the following in aqueous solution is
$I$. $C_6H_5NH_2$
$II$. $(CH_3)_3N$
$III$. $NH_3$
$IV$. $CH_3NH_2$
$V$. $(CH_3)_2NH$

Vedclass Test Series

Exam Paper Generator

Online Exam Module

Assertion : Acylation of amines gives a monosubstituted product whereas alkylation of amines gives polysubstituted product. Reason : Acyl group sterically hinders the approach of further acyl groups.