Which cofactor is essential for the activity | vedclass

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(B) Nitric oxide synthase $(NOS)$ is an enzyme that catalyzes the production of nitric oxide $(NO)$ from $L-arginine$,$oxygen$,and $NADPH$. This enzym

Vedclass · Accepted Answer

$Ca^{2+}/Calmodulin$

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(B) Nitric oxide synthase $(NOS)$ is an enzyme that catalyzes the production of nitric oxide $(NO)$ from $L-arginine$,$oxygen$,and $NADPH$. This enzyme requires several cofactors for its catalytic activity,including $FAD$,$FMN$,$heme$ $(Fe^{2+})$,and $tetrahydrobiopterin$ $(BH_4)$. Additionally,the neuronal and endothelial isoforms of $NOS$ are strictly dependent on the binding of $Ca^{2+}/Calmodulin$ for their activation. Therefore,among the given options,$Ca^{2+}/Calmodulin$ is the essential cofactor/regulator for its activity.

Which cofactor is essential for the activity of nitric oxide synthase?

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