Read the following four statements and identify the two incorrect statements:
$(1)$ The first transgenic buffalo,Rosie,produced milk enriched with human alpha-lactalbumin.
$(2)$ $DNA$ is isolated from large molecules using restriction enzymes.
$(3)$ Downstream processing is a stage of $r$-$DNA$ technology.
$(4)$ Disarmed pathogen vectors are also used to transfer $r$-$DNA$ into the host.

• A
  Statements $(1)$ and $(2)$
• B
  Statements $(2)$ and $(3)$
• C
  Statements $(3)$ and $(4)$
• D
  Statements $(1)$ and $(4)$