Write a note on prophase of mitosis.

(N/A) $ \Rightarrow $ Prophase, which is the first stage of mitosis, follows the $S$ and $G_{2}$ phases of interphase.
$ \Rightarrow $ In the $S$ and $G_{2}$ phases, the new $DNA$ molecules formed are not distinct but intertwined.
$ \Rightarrow $ Prophase is marked by the initiation of condensation of chromosomal material. The chromosomal material becomes untangled during the process of chromatin condensation.
$ \Rightarrow $ The centriole, which had undergone duplication during the $S$ phase of interphase, now begins to move towards opposite poles of the cell.
$ \Rightarrow $ The completion of prophase can be marked by the following characteristic events:
$ \Rightarrow $ Chromosomal material condenses to form compact mitotic chromosomes. Chromosomes are seen to be composed of two chromatids attached together at the centromere.
$ \Rightarrow $ Initiation of the assembly of the mitotic spindle; the microtubules, the proteinaceous components of the cell cytoplasm, help in the process.
$ \Rightarrow $ Although plant cells lack centrioles, the mitotic spindle is still formed.
$ \Rightarrow $ At the end of prophase, the nucleolus, Golgi bodies, endoplasmic reticulum, and nuclear envelope are not seen.
$ \Rightarrow $ Chromosomes spread throughout the cell.