Who proposed the ‘Signal hypothesis’ meant fo | vedclass

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Question

(C) The ‘Signal hypothesis’ was proposed by $G$ünter Blobel and David Sabatini in $1971$.This hypothesis explains how secretory proteins are targeted

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Blobel and Sabatini

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(C) The ‘Signal hypothesis’ was proposed by $G$ünter Blobel and David Sabatini in $1971$.This hypothesis explains how secretory proteins are targeted to the endoplasmic reticulum $(ER)$ during their synthesis.It suggests that a signal sequence at the $N$-terminus of the nascent polypeptide chain directs the ribosome-mRNA complex to the $ER$ membrane,where the protein is then translocated into the lumen of the $ER$.

Who proposed the ‘Signal hypothesis’ meant for the biosynthesis of secretory type of proteins?

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