Which was the first restriction endonuclease isolated and identified?

In vector $\text{pBR-322}$,the $\text{Rop}$ codes for the $:-$

$pBR-322$ is frequently used as a cloning vector. What is it?

Select the correct pair from the following:

Match the enzymes in Column-$I$ with their respective functions in Column-$II$.

Column-$I$	Column-$II$
$P$. Restriction endonuclease	$I$. Synthesizes $DNA$ copies
$Q$. $DNA$ polymerase	$II$. Cleaves $DNA$ molecules
$R$. $DNA$ ligase	$III$. Joins $DNA$ molecules

Which of the following statements are not true regarding restriction endonucleases?
$A$. They are called molecular scissors.
$B$. These are the enzymes responsible for restricting the growth of bacteriophages in $E. coli$.
$C$. They cut the $DNA$ only at the centre of the palindromic sites.
$D$. They remove nucleotides only from the ends of $DNA$ fragments.
$E$. They recognise specific palindromic base-pair sequences.
Choose the answer from the options given below: