Which of the following reaction sequences wou | vedclass

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(C) The reaction of a nitrile with a Grignard reagent followed by acid hydrolysis is a standard method for the synthesis of ketones. $CH_3-CH_2-CH_2-C

Vedclass · Accepted Answer

$CH_3-CH_2-CH_2-CN$ $\xrightarrow[Et_2O]{CH_3MgI}$ $\xrightarrow{H_3O^{+}}$

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(C) The reaction of a nitrile with a Grignard reagent followed by acid hydrolysis is a standard method for the synthesis of ketones. $CH_3-CH_2-CH_2-CN + CH_3MgI$ $\xrightarrow{Et_2O} CH_3-CH_2-CH_2-C(CH_3)=NMgI$ $\xrightarrow{H_3O^{+}} CH_3-CH_2-CH_2-CO-CH_3 + NH_3 + Mg(OH)I$. The product formed is $2$-pentanone. Options $(a)$,$(b)$,and $(d)$ primarily yield alcohols.

Which of the following reaction sequences would be the best for the synthesis of $2$-pentanone?

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