Which of the following is most reactive towar | vedclass

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(A) The reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution depends on the leaving group ability and the electrophilicity

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$CH_3COCl$

Vedclass · Answer

(A) The reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution depends on the leaving group ability and the electrophilicity of the carbonyl carbon.$CH_3COCl$ (acid chloride) is the most reactive because the $Cl^-$ ion is a very good leaving group and the electron-withdrawing effect of the chlorine atom increases the positive charge on the carbonyl carbon,making it highly susceptible to nucleophilic attack.The order of reactivity is: $CH_3COCl > CH_3COOCOCH_3 > CH_3COOCH_3 > CH_3CONH_2$.

Which of the following is most reactive towards nucleophilic attack at the carbonyl group?

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