Which kind of therapy was given in $1990$ to a four-year-old girl with adenosine deaminase $(ADA)$ deficiency?

Which of the following is a correct statement with respect to animal insulin?

The first clinical gene therapy was given for the treatment of .........

Which of the following is/are correct about Adenosine Deaminase $(ADA)$ deficiency?
$I$. In the absence of adenosine deaminase enzyme,purine metabolism is disturbed and $T$-lymphocytes fail to function.
$II$. $ADA$ deficiency is caused by the deletion of the gene for $ADA$.
$III$. In some cases,it can be cured by bone marrow transplantation and enzyme replacement therapy. But in both approaches,the patients are not completely cured.
$IV$. For permanent cure,genes isolated from the bone marrow cells producing $ADA$ at early embryonic stages can be a possible cure.
Which of the above statements are correct?

Identify the correct statement.

Desired genes have been introduced into transgenic animals to obtain large-scale production of useful biological products encoded by these genes. This approach is generally referred to as