What would happen if histones were to be muta | vedclass

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Question

(B) Histones are basic proteins rich in positively charged amino acids like lysine and arginine. These positive charges allow histones to interact wit

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$DNA$ packaging would not occur.

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(B) Histones are basic proteins rich in positively charged amino acids like lysine and arginine. These positive charges allow histones to interact with the negatively charged phosphate backbone of $DNA$. If histones were mutated to be rich in acidic amino acids (like aspartic acid and glutamic acid),they would become negatively charged. Since $DNA$ is also negatively charged,electrostatic repulsion would occur between the mutated histones and $DNA$. Consequently,the packaging of $DNA$ into nucleosomes would not occur,and chromatin fibers would not be formed.

What would happen if histones were to be mutated and made rich in acidic amino acids such as aspartic acid and glutamic acid in place of basic amino acids such as lysine and arginine?

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