What is Human Genome Project ?
Genetic make up of an organism or an individual lies in the $DNA$ sequences.
If two individuals differ, then their $DNA$ sequences should also be different, at least at some places.
These assumptions led to the quest of finding out the complete $DNA$ sequence of human genome.
With the establishment of genetic engineering techniques where it was possible to isolate and clone any piece of $DNA$ sequences, a very ambitions project of sequencing human genome was launched in the year $1990$ .
Human genome project [$HGP$]was called a mega project.
We can imagine the magnitude and the requirements for the project if we simply define the aims of the project as follows :
- Human genome is said to have approximately $3 $$\times 10^{9} \mathrm{bp}$ and if the cost of sequencing required is $US$ $3$ per bp, the total estimated cost of the project would be approximately $9$ billion $US$ dollars.
Further, if the obtained sequences were to be stored in typed form in books and if each page of the book contained $1000$ letters and each book contained $1000$ pages, then $3300$ such books would be required to store the information of $DNA$ sequence from a single human cell.
The enormous amount of data expected to be generated also necessitated the use of high speed computational devices for data storage and retrieval and analysis.
$HGP$ was closely associated with the rapid development of a new area in biology called Bioinformatics.
What is $DNA$ polymorphism ? Why is it important to study it ?
If a geneticist uses the blind approach for sequencing the whole genome of an organism, followed by assignment of function to different segments, the methodology adopted by him is called as :
Which of the following is Not a goal of the human genome project?
Expressed Sequence Tages $(ESTs)$ refers to
The genome map was produced under human genome project in: