What happens in Hamburger shift?

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Question

(A) The process of $CO_{2}$ transport involves the reaction: $CO_{2} + H_{2}O \xrightarrow{	ext{Carbonic Anhydrase}} H_{2}CO_{3} ightleftharpoons H

Vedclass · Accepted Answer

$HCO_{3}^{-}$ ions move out from $RBC$ and $Cl^{-}$ ions enter into $RBC$.

Vedclass · Answer

(A) The process of $CO_{2}$ transport involves the reaction: $CO_{2} + H_{2}O \xrightarrow{	ext{Carbonic Anhydrase}} H_{2}CO_{3} ightleftharpoons HCO_{3}^{-} + H^{+}$.To maintain the electrical neutrality of the $RBC$ and plasma,$HCO_{3}^{-}$ ions diffuse out of the $RBC$ into the plasma,and an equivalent amount of $Cl^{-}$ ions move from the plasma into the $RBC$. This phenomenon is known as the Hamburger shift or chloride shift.As a result,the chloride content of the $RBC$ increases when oxygenated blood becomes deoxygenated (venous blood),making the $Cl^{-}$ concentration in venous $RBC$s significantly higher than in arterial $RBC$s.

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