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(C) The semi-conservative nature of $DNA$ replication was experimentally proven by Matthew Meselson and Franklin Stahl in $1958$.They used the bacteri

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$Escherichia$ $coli$

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(C) The semi-conservative nature of $DNA$ replication was experimentally proven by Matthew Meselson and Franklin Stahl in $1958$.They used the bacterium $Escherichia$ $coli$ $(E. coli)$ as their experimental model system.They grew $E. coli$ in a medium containing $^{15}N$ (a heavy isotope of nitrogen) for many generations to label the $DNA$ with heavy nitrogen.Then,they transferred these cells to a medium containing $^{14}N$ (the normal isotope) and extracted the $DNA$ at various time intervals to observe the density of the $DNA$ molecules using cesium chloride $(CsCl)$ density gradient centrifugation.This experiment confirmed that each new $DNA$ molecule consists of one old strand and one newly synthesized strand.

The experimental system used in studies of the discovery of semi-conservative replication of $DNA$ was:

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