The binding of oxygen by haemoglobin $(Hb)$ forming $(HbO_2)$ is partially regulated by the concentration of $H_3O^{+}$ and dissolved $CO_2$ in blood.
$HbO_2 + H_3O^{+} + CO_2 \rightleftharpoons (H^{+} - Hb - CO_2) + O_2 + H_2O$
Release of $O_2$ is favoured when there is:

  • A
    Production of $CO_2$ during exertion
  • B
    Production of lactic acid during exertion
  • C
    Both $(A)$ and $(B)$ take place
  • D
    Releasing of haemoglobin during exertion

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