Sickle­cell anaemia is

  • [AIPMT 2009]
  • A

    caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin

  • B

    caused by a change in a single base pair of $DNA$

  • C

    characterized by elongated sickle like $RBCs$ with a nucleus

  • D

    an autosomal linked dominant trait.

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Column $-I$ Column $-II$
$a.$ Solid symbol $(i)$ Carrier of sex linked trait
$b.$ Horizontal line between symbols $(ii)$ Offspring
$c.$ Horizontal line above the symbols $(iii)$ Trait to be studied
$d.$ Dot in centre $(iv)$ Parents