Sickle cell anaemia is

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(B) Sickle cell anaemia is an autosomal recessive genetic disorder.It is caused by a point mutation in the gene coding for the $\beta$-globin chain of

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Caused by substitution of glutamic acid by valine in the $\beta$-globin chain of haemoglobin

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(B) Sickle cell anaemia is an autosomal recessive genetic disorder.It is caused by a point mutation in the gene coding for the $\beta$-globin chain of haemoglobin.Specifically,the amino acid glutamic acid at the $6^{th}$ position is replaced by valine due to a single base pair substitution ($GAG$ to $GUG$ in $mRNA$).This change leads to the formation of abnormal haemoglobin,causing $RBCs$ to become sickle-shaped under low oxygen tension.

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