Sickle cell anaemia is

  • A

    An autosomal linked dominant trait

  • B

    Caused by substitution of glutamic acid by valic acid in the $\beta$-globin chain of haemoglobin

  • C

    Caused by a change in $3$ base pairs of $DNA$

  • D

    Characterized by elongated sickle like $RBCs$ with a nucleus

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  • [NEET 2017]