Sickle cell anaemia is due to

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(C) Sickle cell anaemia is an autosomal recessive genetic disorder caused by a point mutation in the $\beta$-globin gene of the haemoglobin molecule.T

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$A$ genetically determined defect of haemoglobin synthesis

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(C) Sickle cell anaemia is an autosomal recessive genetic disorder caused by a point mutation in the $\beta$-globin gene of the haemoglobin molecule.This mutation leads to the substitution of glutamic acid by valine at the $6^{th}$ position of the $\beta$-globin chain.As a result,the haemoglobin molecule undergoes polymerisation under low oxygen tension,causing the red blood cells to change their shape from biconcave discs to elongated sickle-like structures.

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