Sickle cell anaemia is caused due to the subs | vedclass

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(D) is the correct answer. Sickle-cell anaemia is an autosomal recessive genetic disorder. It is caused by a point mutation in the gene coding for the

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glutamic acid at the $6^{	ext{th}}$ position of beta globin chain by valine

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(D) is the correct answer. Sickle-cell anaemia is an autosomal recessive genetic disorder. It is caused by a point mutation in the gene coding for the $\beta$-globin chain of haemoglobin. Specifically,the $6^{	ext{th}}$ amino acid of the $\beta$-globin chain,which is normally glutamic acid,is replaced by valine. This substitution changes the structure of the haemoglobin molecule,causing red blood cells to become sickle-shaped under low oxygen conditions.

Sickle cell anaemia is caused due to the substitution of

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