Replacement of which one of the following nuc | vedclass

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(A) Sickle cell anaemia is caused by a point mutation in the $Hb^A$ gene.Specifically,a single nucleotide substitution occurs in the $DNA$ sequence wh

Vedclass · Accepted Answer

$A$ to $T$

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(A) Sickle cell anaemia is caused by a point mutation in the $Hb^A$ gene.Specifically,a single nucleotide substitution occurs in the $DNA$ sequence where the nucleotide $Adenine$ $(A)$ is replaced by $Thymine$ $(T)$.This mutation changes the codon $GAG$ to $GTG$ at the sixth position of the $\beta$-globin chain.Consequently,the amino acid $Glutamic$ $acid$ is replaced by $Valine$ at the sixth position of the hemoglobin protein,leading to the formation of abnormal $Hb^S$ hemoglobin.

Replacement of which one of the following nucleotides in the $Hb^A$ gene causes sickle cell anaemia?

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