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Question

(A) $SCID$ (Severe Combined Immunodeficiency) is caused by a defect in the gene for the enzyme adenosine deaminase $(ADA)$. In enzyme replacement ther

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Transfused cells have a limited life span

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(A) $SCID$ (Severe Combined Immunodeficiency) is caused by a defect in the gene for the enzyme adenosine deaminase $(ADA)$. In enzyme replacement therapy,functional $ADA$ is injected into the patient. However,these enzymes and the genetically modified cells used in gene therapy have a limited life span and are not immortal. Therefore,they do not remain in the body permanently and must be periodically replenished to maintain therapeutic levels of the enzyme.

Repeated transfusions of genetically modified cells are required in $SCID$ patients and in enzyme replacement therapy because

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