In which disease is $\alpha-1$ antitrypsin used for treatment?

Genetic engineering is connected with

The first clinical application of gene therapy was used in $1990$ on a four-year-old girl for:

The vector used for delivery of $ADA$ $cDNA$ into cells of a patient receiving gene therapy is

Find the correct statements from the following:
$I.$ Gene therapy is a genetic engineering technique used to treat diseases at the molecular level.
$II.$ Calcitonin is a medically useful recombinant product in the treatment of infertility.
$III.$ Bt toxin is a biodegradable insecticide obtained from $Bacillus \text{ } thuringiensis$.

The human protein named $\alpha-1$-antitrypsin,obtained from transgenic animals,is used for the treatment of . . . . . . .