Goeddel and his associates biosynthesized the $HGH$ by genetic engineering by:

• A
  $RNA$ incorporation into $E. coli$
• B
  $DNA$ of somatostatin gene incorporated into $E. coli$ near the chromosome containing genes for coding the beta-galactosidase
• C
  Incorporation of $DNA$ of $HGH$ into plasmids of $E. coli$
• D
  Incorporation of $RNA$ of $HGH$ into plasmids of $E. coli$