| Restriction Endonuclease | Restriction Exonuclease |
|---|---|
| $(1)$ Endonucleases cut $DNA$ molecules at specific internal positions. | $(1)$ Exonucleases remove nucleotides sequentially from the ends of the $DNA$ molecule. |
| $(2)$ They often produce sticky or blunt ends depending on the enzyme. | $(2)$ They generally do not produce sticky ends as they act on the termini. |
| $(3)$ They are essential tools in recombinant $DNA$ technology for creating gene fragments. | $(3)$ They are primarily involved in $DNA$ repair and degradation processes. |
| $(4)$ Examples include $BamHI$, $HindIII$, $EcoRI$. | $(4)$ Examples include $Exonuclease III$, $RecJ$. |
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