Enzymes are best defined as

Regarding the catalytic cycle of an enzyme action,select the correct sequential steps:
$A$. Substrate-enzyme complex formation.
$B$. Free enzyme ready to bind with another substrate.
$C$. Release of products.
$D$. Chemical bonds of the substrate broken.
$E$. Substrate binding to active site.
Choose the correct answer from the options given below:

Which of the following enzymes becomes inactive when its shape is altered?

$A$ non-proteinaceous enzyme is

Inorganic catalysts work efficiently at . . . . . . temperature and . . . . . . pressure.

Assertion : Enzymes have active sites and substrates have reactive sites on their surface respectively.
Reason : Active and reactive sites push the enzyme and substrate molecules away from each other.