| $1$. Plasmid $DNA$ is autonomously replicable, whereas Chromosomal $DNA$ replicates under nuclear control. |
| $2$. Plasmid $DNA$ is double-stranded and circular, while Chromosomal $DNA$ can be double-stranded, circular, or linear. |
| $3$. Plasmid $DNA$ is not associated with histones, whereas Chromosomal $DNA$ is associated with histone proteins. |
| $4$. Plasmid $DNA$ contains few genes for traits like antibiotic resistance, while Chromosomal $DNA$ contains genes for essential metabolic functions. |
| $1$. $RNA$ contains ribose sugar, whereas $DNA$ contains deoxyribose sugar. |
| $2$. $RNA$ is typically single-stranded, while $DNA$ is double-stranded. |
| $3$. $RNA$ contains uracil, whereas $DNA$ contains thymine. |
| $4$. $RNA$ is less stable due to the $2'-OH$ group, while $DNA$ is more stable. |
| $1$. Exonucleases remove nucleotides from the ends of $DNA$, whereas Endonucleases cut $DNA$ at specific internal sites. |
| $2$. Exonucleases often produce blunt ends, while Endonucleases can produce sticky ends. |
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