Discuss the process of translation in detail.

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(N/A) Translation refers to the process of polymerisation of amino acids to form a polypeptide. Ribosome is the site of protein synthesis. The amino acids are joined by a bond which is known as a peptide bond. Formation of a peptide bond requires energy. Therefore,in the first phase itself,amino acids are activated in the presence of $ATP$ and linked to their respective $tRNA$—a process commonly called activation or charging of $tRNA$,or aminoacylation of $tRNA$ to be more specific.
If two such charged $tRNAs$ are brought close enough,the formation of a peptide bond between them would be favoured energetically. The presence of a catalyst would enhance the rate of peptide bond formation. The cellular factory responsible for synthesising proteins is the ribosome. The ribosome consists of structural $RNAs$ and about $80$ different proteins. In its inactive state,it exists as two subunits: a large subunit and a small subunit.
When the small subunit encounters an $mRNA$,the process of translation of the $mRNA$ to protein begins. There are two sites in the large subunit for subsequent amino acids to bind to and thus be close enough to each other for the formation of a peptide bond. The ribosome also acts as a catalyst ($23S$ $rRNA$ in bacteria is the enzyme-ribozyme) for the formation of a peptide bond.
$A$ translational unit in $mRNA$ is the sequence of $RNA$ that is flanked by the start codon $(AUG)$ and the stop codon and codes for a polypeptide. An $mRNA$ also has some additional sequences that are not translated and are referred to as untranslated regions $(UTR)$. The $UTRs$ are present at both $5^{\prime}$-end (before start codon) and at $3^{\prime}$-end (after stop codon). They are required for efficient translation process.
For initiation,the ribosome binds to the $mRNA$ at the start codon $(AUG)$ that is recognised only by the initiator $tRNA$. The ribosome proceeds to the elongation phase of protein synthesis. During this stage,complexes composed of an amino acid linked to $tRNA$ sequentially bind to the appropriate codon in $mRNA$ by forming complementary base pairs with the $tRNA$ anticodon. The ribosome moves from codon to codon along the $mRNA$.

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Similar Questions

Where are the Untranslated Regions $(UTRs)$ located?

Read the following statements and choose the correct set of statements:
$(a)$ $\text{tRNA}$ has an anticodon loop that has bases complementary to the code.
$(b)$ The $\text{tRNA}$,also called $\text{sRNA}$,was known before the genetic code was postulated.
$(c)$ For termination codon,there is a specific $\text{tRNA}$ that is referred to as terminator $\text{tRNA}$.
$(d)$ The secondary structure of $\text{tRNA}$ has been depicted that looks like an inverted $L$.
Choose the correct answer from the options given below:

Which of the following characteristics is not applicable to $tRNA$?

In eukaryotes,the anticodon of $t-RNA$ that pairs with the start codon of $mRNA$ during translation is

What are anticodons?

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