Diabetes mellitus is due to the lack of:

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(D) $Diabetes \ mellitus$ is a metabolic disorder characterized by high blood glucose levels (hyperglycemia).It is primarily caused by the deficiency

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Insulin in blood

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(D) $Diabetes \ mellitus$ is a metabolic disorder characterized by high blood glucose levels (hyperglycemia).It is primarily caused by the deficiency or ineffective action of the hormone $Insulin$,which is secreted by the $\beta$-cells of the $Islets \ of \ Langerhans$ in the pancreas.$Insulin$ is essential for the uptake of glucose by cells and for maintaining blood sugar homeostasis.Therefore,the correct option is $D$.

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