Describe Replication of $DNA$ and Give experimental proof for it.
In addition to the double helical structure of $DNA$, Watson and Crick also proposed a scheme of $DNA$ replication.
To quote their original statement that is as follows :
$(i)$ It has not escaped our notice that the specific pairing copying mechanism for the genetic material (Watson and Crick, $1953$).
$(ii)$ The scheme suggested that the two strands would separately and act as template for the synthesis of new complementary strands.
$(iii)$ After the completion of replication, each $DNA$ molecule would have one parental and one newly synthesise strand.
$(iv)$ This scheme was termed as semiconservative $DNA$ replication.
It is proven that $DNA$ replicates semiconservatively.
It was shown first in Escherichia coli and subsequently in higher organisms, such as plants and human cells.
Mathew Meselson and Franklin Stahl performed the following experiment in $1958:$
$(i)$ They grew E. coli in a medium containing ${ }^{15} \mathrm{NH}_{4} \mathrm{Cl}\left[{ }^{15} \mathrm{~N}\right.$ is the heavy isotope of nitrogen] as the only nitrogen source for many generations.
The result was that ${ }^{15} \mathrm{~N}$ was incorporated into newly synthesised $DNA$ (as well as other nitrogen containing compounds).
Which of the following figures correctly represents the replication fork formed during $DNA$ replication
Discuss the significance of heavy isotope of nitrogen in the Meselson and Stahl’s experiment.
$DNA$ replication is
Which of the following statement is correct regarding the process of replication in $E$.coli?
It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for genetic material. This is written by