Anaphase Promoting Complex (APC) is a protein | vedclass

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(B) $APC$ (Anaphase Promoting Complex) is an E3 ubiquitin ligase that triggers the transition from metaphase to anaphase by tagging specific proteins

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Chromosomes will not segregate.

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(B) $APC$ (Anaphase Promoting Complex) is an E3 ubiquitin ligase that triggers the transition from metaphase to anaphase by tagging specific proteins (like securin and cyclin $B$) for degradation. Securin degradation releases the enzyme separase,which cleaves the cohesin proteins holding sister chromatids together. If $APC$ is defective,these proteins are not degraded,cohesin remains intact,and sister chromatids fail to separate. Therefore,the chromosomes will not segregate to opposite poles.

Anaphase Promoting Complex $(APC)$ is a protein degradation machinery necessary for proper mitosis of animal cell. If $APC$ is defective in a human cell,which of the following is expected to occur?

Similar Questions

Match the following and select the correct option:
$List-I$ (Phase) | $List-II$ (Event)
$(A)$ Prophase | $(i)$ Centromere attaches to spindle fibers
$(B)$ Metaphase | $(ii)$ Spindle fibers disappear
$(C)$ Anaphase | $(iii)$ Formation of spindle fibers
$(D)$ Telophase | $(iv)$ Spindle fibers shorten

Which one of the following precedes the reformation of the nuclear envelope during the $M-$phase of the cell cycle?

Into how many stages is mitosis divided?

Small disc-shaped structures at the surface of the centromeres that appear during metaphase are

In which stage of cell division are chromosomes most condensed?

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