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(D) The chemosensitive area is located adjacent to the respiratory rhythm centre in the medulla oblongata of the brain.This area is highly sensitive t

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Both $(a)$ and $(c)$

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(D) The chemosensitive area is located adjacent to the respiratory rhythm centre in the medulla oblongata of the brain.This area is highly sensitive to changes in the concentration of $CO_{2}$ and $H^{+}$ ions in the blood.An increase in $CO_{2}$ and $H^{+}$ concentrations activates this chemosensitive area,which in turn signals the rhythm centre to make necessary adjustments in the respiratory process to eliminate these substances.Since $CO_{2}$ concentration influences blood $pH$ by forming $HCO_{3}^{-}$ and $H^{+}$ ions (facilitated by the enzyme carbonic anhydrase),both $CO_{2}$ and $H^{+}$ are critical factors for this regulation.

$A$ chemosensitive area is situated adjacent to the rhythm centre in the brain. This area is highly sensitive to

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