Determine the configuration of the chiral cen | vedclass

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(B) To determine the configuration,we assign priorities to the groups attached to each chiral carbon using Cahn-Ingold-Prelog $(CIP)$ rules.For $C-2$

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$2S, 3R$

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(B) To determine the configuration,we assign priorities to the groups attached to each chiral carbon using Cahn-Ingold-Prelog $(CIP)$ rules.For $C-2$ (top chiral center):$1$. $-OH$ (priority $1$)$2$. $-CH(Br)CH_3$ (priority $2$)$3$. $-CH_3$ (priority $3$)$4$. $-H$ (priority $4$)Since the lowest priority group $(-H)$ is on the horizontal line,the configuration is reversed. The sequence $1$ $\rightarrow 2$ $\rightarrow 3$ is clockwise $(R)$,so it becomes $S$. Thus,$C-2$ is $2S$.For $C-3$ (bottom chiral center):$1$. $-Br$ (priority $1$)$2$. $-CH(OH)CH_3$ (priority $2$)$3$. $-CH_3$ (priority $3$)$4$. $-H$ (priority $4$)Since the lowest priority group $(-H)$ is on the horizontal line,the configuration is reversed. The sequence $1$ $\rightarrow 2$ $\rightarrow 3$ is counter-clockwise $(S)$,so it becomes $R$. Thus,$C-3$ is $3R$.Therefore,the configuration is $2S, 3R$.

Determine the configuration of the chiral centers in the given structure.

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