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| Column – $I$ | Column – $II$ |
|---|---|
| $(1)$ Failure of cytokinesis | $(p)$ To study inheritance of particular traits |
| $(2)$ Trisomy of $21$ | $(q)$ Polyploidy |
| $(3)$ Error of metabolism | $(r)$ Down's syndrome |
| $(4)$ Pedigree analysis | $(s)$ Phenylketonuria |
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