Which of the following is a characteristic of pernicious anemia?

Match the following:
Types of leucocytes | Function
$A.$ Neutrophils | $1.$ Heparin and histamine secretion
$B.$ Basophils | $2.$ Antibodies formation
$C.$ Acidophils | $3.$ Scavenger
$D.$ Monocytes | $4.$ Phagocytes
$E.$ Lymphocytes | $5.$ Antiallergic and healing of wounds
The correct pairing sequence is:

Analogy type questions:
$(1)$ Fish : Single circulation :: Amphibians : ...........
$(2)$ Between right atrium and right ventricle : Tricuspid valve :: Between left atrium and left ventricle : .............

The breakdown product of haemoglobin is

Assertion $A$: In an open circulatory system,the blood volume is high,but the blood pressure is low and irregular.
Reason $R$: In a closed circulatory system,the blood volume is limited,and the blood pressure is high and regular.
Which option is correct for Assertion $A$ and Reason $R$?

Statement-$I$: The first heart sound $(lub)$ is associated with the opening of the tricuspid and bicuspid valves.
Statement-$II$: Cardiac output of an athlete is much higher than that of an ordinary man.