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(D) The characteristic shivering and high fever in malaria are caused by the release of a toxic substance called $hemozoin$ into the blood. This $hemo

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Release of merozoites from $RBC$s along with a toxin.

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(D) The characteristic shivering and high fever in malaria are caused by the release of a toxic substance called $hemozoin$ into the blood. This $hemozoin$ is released when the $Plasmodium$ parasite completes its asexual cycle within the red blood cells ($RBC$s). As the $RBC$s rupture,they release the mature merozoites along with the toxic $hemozoin$,which triggers the immune response leading to chills and shivering.

The characteristic shivering in malaria is caused by which of the following?

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