The first heart sound is associated with which of the following?

Which one of the following statements is correct?

The accompanying diagram shows the three stages in the cardiac cycle. Which of the following is the correct sequence?

$A$: Isovolumetric systole of a normal cardiac cycle is responsible for the opening of semilunar valves causing the blood flow into aortic aorta and pulmonary aorta.
$R$: During isovolumetric systole,intraventricular pressure increases as semilunar and $AV$ valves are closed and ventricles are contracting.

During ventricular diastole:

In humans,the volume of blood pumped out by each ventricle per minute is