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(A) The aerobic oxidation of one molecule of pyruvate involves the link reaction and the Krebs cycle.
$1$. Link reaction: $1$ Pyruvate + $1$ CoA + $1

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(A) The aerobic oxidation of one molecule of pyruvate involves the link reaction and the Krebs cycle.
$1$. Link reaction: $1$ Pyruvate + $1$ CoA + $1$ $NAD^+$ $ightarrow$ $1$ Acetyl-CoA + $1$ $NADH$ + $1$ $CO_2$.
$2$. Krebs cycle: $1$ Acetyl-CoA + $3$ $NAD^+$ + $1$ $FAD$ + $1$ $GDP$ + $1$ $Pi$ + $2$ $H_2O$ $ightarrow$ $2$ $CO_2$ + $3$ $NADH$ + $1$ $FADH_2$ + $1$ $GTP$ + $1$ CoA.
Total $NADH$ produced = $1$ (link) + $3$ (Krebs) = $4$ $NADH$.
Total $FADH_2$ produced = $1$ $FADH_2$.
In the Electron Transport System $(ETS)$,the oxidation of $1$ $NADH$ requires $0.5$ $O_2$ and $1$ $FADH_2$ requires $0.5$ $O_2$.
Total $O_2$ required = $(4 	imes 0.5) + (1 	imes 0.5) = 2 + 0.5 = 2.5$ molecules of $O_2$ per pyruvate.
The balanced equation for the complete oxidation of pyruvate is: $CH_3COCOOH + 2.5 O_2 ightarrow 3 CO_2 + 2 H_2O$. Thus,$2.5$ molecules of $O_2$ are required.

Column $A$	Column $B$
$A$. Molecular oxygen	$(i)$. $\alpha$-Ketoglutaric acid
$B$. Electron acceptor	$(ii)$. Hydrogen acceptor
$C$. Pyruvate dehydrogenase	$(iii)$. Cytochrome $c$
$D$. Decarboxylation	$(iv)$. Acetyl $CoA$

What is the number of oxygen molecules required for the aerobic oxidation of one molecule of pyruvate (in $.5$)?

Similar Questions

Given below are two statements:
Statement-$I$: Acetyl $CoA$ formation takes place by oxidative decarboxylation of pyruvic acid.
Statement-$II$: $\beta$-oxidation of fatty acid produces acetyl $CoA$.
In the light of above statements,choose the most appropriate answer from the options given below.

Assertion : Glycolysis is the first step of respiration in which glucose completely breaks into $CO_2$ and $H_2O$.
Reason : In this process,there is net gain of twenty four molecules of $ATP$.

The rate of respiration can be checked (inhibited) by:

Match the following and choose the correct option from those given below.

Column $A$ Column $B$

$A$. Molecular oxygen $(i)$. $\alpha$-Ketoglutaric acid

$B$. Electron acceptor $(ii)$. Hydrogen acceptor

$C$. Pyruvate dehydrogenase $(iii)$. Cytochrome $c$

$D$. Decarboxylation $(iv)$. Acetyl $CoA$

Decarboxylation is not involved in

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