Transgenic models do not exist for which of the following diseases?

Consider the following statements:
$I$. Transgenic animals are more sensitive to toxic substances than non-transgenic animals.
$II$. Useful biological products can be produced by introducing into transgenic animals the portion of $DNA$ which codes for a particular product.
$III$. Brazzein is a protein produced by a West African plant,$Pentadiplandra$ $brazzeana$,which is approximately $2000$ times as sweet as sugar.
Which of the statements given above are correct?

If a cattle is showing increased respiration and blood mixed foamy discharge from mouth,nose,and anus,it is likely to be suffering from

Transgenic models exist for which of the following human diseases:
$(a)$ Cancer $(b)$ Cystic fibrosis $(c)$ Rheumatoid arthritis $(d)$ Alzheimer's disease $(e)$ Emphysema

Name the first transgenic cow. Which gene was introduced in this cow?

Which of the following is known as toxicity/safety testing in the context of transgenic animals?