Describe Mendelian Disorder.
Describe Mendelian Disorder.
Mendelian disorders are mainly determined by alternation or mutation in the single gene.
These disorders are transmitted to the offspring on the same lines as the principle of inheritance
The pattern of inheritance of Mendelian disorders can be traced in a family by the pedigree analysis.
Most common and prevalent Mendelian disorders can be traced in a family by the pedigree analysis.
Most common and prevalent Mendelian disorder are Haemophilia, Cystic fibroses, Sickle cell anaemia, Colour blindness, Phenylketonuria, Thalassemia etc.
Such Mendelian disorder may be dominant or recessive.
By pedigree analysis one can easily understand whether the trait in question is dominant or recessive.
Similarly the trait may also be linked to the sex chromosome as in case of haemophilia.
It is evident that this $X$-linked recessive trait shows transmission from carrier female to male progeny.
A representative pedigree is shown in figure for dominant and recessive traits.
Colour blindness is sex linked recessive disorder due to defect in either red or green cone of eye resulting in failure to discriminate between red and green colour.
Similar Questions
In the above pedigree, assume that no outsider marrying in, carry a disease. Write the genotypes of $C$ and $D$.
In the above pedigree, assume that no outsider marrying in, carry a disease. Write the genotypes of $C$ and $D$.
It is said, that the harmful alleles get eliminated from population over a period of time, yet sickle cell anaemia is persisting in human population. Why ?
It is said, that the harmful alleles get eliminated from population over a period of time, yet sickle cell anaemia is persisting in human population. Why ?
A normal woman whose father was colourblind marries a normal man. What kinds of children would be expected and in what proportion
A normal woman whose father was colourblind marries a normal man. What kinds of children would be expected and in what proportion
A woman with normal vision, but whose father was colour blind, marries a colour blind man. Suppose that the fourth child of this couple was a boy. Thus boy
A woman with normal vision, but whose father was colour blind, marries a colour blind man. Suppose that the fourth child of this couple was a boy. Thus boy
- [AIPMT 2005]
In which of the following colourblindness is inherited
In which of the following colourblindness is inherited